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  • 정상택 교수
  • Assistant Professor
  • Protein Engineering
  • Ph.D. University of Texas at Austin
  • Webpage : http://pel.kookmin.ac.kr/
  • E-mail : sjung@kookmin.ac.kr
  • Tel/ Room : (office) +82-2-910-5769 , (lab) +82-2-910-5605
  • Location : (office) Room 708 [Dormitory D], (lab) Room 102 [Science B/D]

Education

B. S. Chemical Technology (Renamed Chemical and Biological Engineering), Seoul National University (1997)



M.S. Chemical Technology (Renamed Chemical and Biological Engineering), Seoul National University (1999)



Ph.D. Chemical Engineering, The University of Texas at Austin, (Austin, TX) (2009)

Career

Researcher, Central Research Center, Green Cross Corporation (Dec. 1998 – Apr. 2001)


Research Scientist, Samyang Genex Biotech Research Institute (May 2001 – Mar. 2004)


Post-Doctoral Fellow, Department of Chemical Engineering, The University of Texas at Austin (Aug. 2009 – May 2010)


Post-Doctoral Fellow, Division of Chemistry and Chemical Engineering, California Institute of Technology (Jun. 2010 – May 2011)


Research Associate, Staff Scientist, Department of Chemical Engineering, The University of Texas at Austin (May 2011 – Aug. 2012)

Research Topics

● Protein engineering


Antibody engineering


Enzyme engineering


● Applied immunology

Selected publications

S. T. Jung, W. Kelton, T. H. Kang, J. T. Andersen, I. Sandlie, G. Georgiou, (2012) ”Aglycosylated IgG variant with selective binding to FcγRIIa and improved phagocytosis of tumor cells”, ACS Chemical Biology, in press.


E. M. Brustad, V. S. Lelyveld, C. D. Snow, N. Crook, S. T. Jung, F. M. Martinez, T. J. Scholl, A. Jasanoff, F. H. Arnold, (2012) “Structure-guided directed evolution of highly selectively P450-based magnetic resonance imaging sensors for dopamine and serotonin”, Journal of Molecular Biology, 422:2, 245-262.


M. J. Borrok, S. T. Jung, T. H. Kang, A. F. Monzingo, G. Georgiou, (2012) ”Structural consequences of the aglycosylated human IgG Fc domain revisited”, ACS Chemical Biology, 7:9, 1596-1602.


S. T. Jung, T. H. Kang, W. Kelton, G. Georgiou, (2011) “Bypassing glycosylation: Engineering aglycosylated full length IgG antibodies for human therapy, Current Opinion in Biotechnology, 22:6, 858-867.


S. T. Jung, R. Lauchli, F. H. Arnold, (2011), “Cytochrome P450: taming a wild type enzyme”, Current Opinion in Biotechnology, 22:6, 809-817.


J. Qiu, S. T. Jung, G. Georgiou, H. Hang, (2010), “Enrichment of Escherichia coli spheroplasts displaying scFv antibodies specific for antigens expressed on the

human cell surface”, Applied Microbiology and Biotechnology, 88:6, 1385-1391.


S. T. Jung, T. H. Kang, G. Georgiou (2010), “Efficient expression and purification of human aglycosylated Fcγ receptors in Escherichia coli”, Biotechnology and Bioengineering, 197:1, 21-30.


S. T. Jung, S. T. Reddy, T. H. Kang, M. J. Borrok, I. Sandlie, P. W. Tucker, G. Georgiou (2010), “Aglycosylated IgG variants expressed in bacteria that selectively bind FcγRI potentiate tumor cell killing by monocyte-dendritic cells”, Proceedings of the National Academy of Sciences USA (PNAS), 107:2, 604-609.


Highlighted in Nature Biotechnology (2010), 28:1, 45, “Research Highlights”, “Receptor-selective aglycosylated Abs”,


Highlighted in Nature SciBX (Science Business eXchange) (2010), 3:3, Jan 21, 2010 issue, “Cover Story”, “mAbs that live long and prosper”,

http://www.nature.com/scibx/journal/v3/n3/full/scibx.2010.73.html


S. T. Jung, K. J. Jeong, B.L. Iverson, G. Georgiou (2007), “Binding and enrichment of Escherichia coli spheroplasts expressing inner membrane tethered scFv antibodies on surface immobilized antigens”, Biotechnology and Bioengineering, 98:1, 39-47.


Highlighted “Spotlight” Biotechnology and Bioengineering (2007), 98:1, “Toward the Isolation of Antibodies to Surface Biomarkes”.