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  • 유연규 교수
  • Professor
  • Biochemistry
  • Ph.D. University of California (UCLA)
  • Webpage :
  • E-mail : ygyu@kookmin.ac.kr
  • Tel/ Room : (office) +82-2-910-5421 , (lab) +82-2-910-5264 , 5889
  • Location : (office) Room 614 [Dormitory D], (lab) Room 519-1 , 516 [Science B/D]

Education

- B.Sc., Seoul National University, Department of Chemistry


- M.Sc., Seoul National University, Department of Chemistry


- Ph. D., University of California, Los Angeles, Department of Chemistry and Biochemistry

Career

- Post Doctoral Researcher, University of California, Berkeley, Department of Chemistry (Oct. 1993 - Feb. 1995)


- Senior Scientist and Principal Scientist, Korea Institute of Science and Technology ( KIST ) (Feb. 1995 - Feb. 2005)


- Professor, Department of Bio- and Nano-Chemistry, Kookmin University. (Mar. 2005 - Present)

Research Topics

‘ Structure-function relationship of membrane proteins and protein-interaction regulation ’


- Structural and functional study of membrane proteins.


- The interaction and regulation of CK2 by hNopp140, an intrinsically unstructured protein (IUP)

Selected publications

“Fragment-based discovery of novel and selective mPGES-1 inhibitors Part1: Identification of sulfonamido-1,2,3-triazole-4,5-dicarboxylic acid”, K. Lee, V. C. Pham, M. J. Choi, K. J. Kim, K-. T. Lee, S-. G. Han, Y. G. Yu, J. Y. Lee, Bioorg. Med. Chem. Lett., 2013, 23, 75p


“Bacterially expressed human serotonin receptor 3A is functionally reconstituted in proteoliposomes”, J-. H. Na, J. Shin, Y. Jung, D. Lim, Y-. K. Shin, Y. G. Yu, Protein Exp. Puri., 2013, 88, 190p


“Identification of novel mPGES-1 inhibitors through screening of a chemical library”, S-. J. Park, S-. G. Han, H. M. Ahsan, K. Lee, J. Y. Lee, J-. S. Shin, K-.T Lee, N-. S. Kang, Y. G. Yu, Bioorg. Med. Chem. Lett., 2012, 22, 7335p


“Mitoxantrone Binds to Nopp140, an Intrinsically Unstructured Protein, and Modulate its Interaction with Protein Kinase CK2”, W-. K. Lee, S. Y. Lee, J-. H. Na, S. Jang, C. R. Park, S-. Y. Kim, S-. H. Lee, K-. H. Han, Y. G. Yu, Bull. Korean Chem Soc., 2012, 33(6), 2005p “Cover article”


“Purification and characterization of recombinant human endothelin receptor type A”, K. Lee, Y. Jung, J. Y. Lee, W-. K. Lee, D. Lim, Y. G. Yu, Protein Exp. Puri., 2012, 84, 14p


“Kinetic Properties of Wild-type and C117D Mutant UDP-N-Acetylglucosamine Enolpyruvyl Transferase (MurA) from Haemophilus influenza”, S-. G. Han, B-. S. Jin, W-. K. Lee, Y. G. Yu, Bull. Korean Chem Soc., 2011, 32(8), 2549p


“Identification of dinitrotoluene selective peptides by phage display cloning”, H-. J. Jang, J-. H. Na, B-. S Jin, W-. K. Lee, W-. H. Lee, H. J. Jung, S-. C Kim, S-. H. Lim, Y. G. Yu, Bull. Korean Chem Soc., 2010, 31(12), 3703p


“Development of a Coupled Enzyme Assay Method for Microsomal Prostaglandin E Synthase Activity”, K. A. Choi, S. J. Park, Y. G. Yu, Bull. Korean Chem. Soc., 2010, 31(2), 384p


“Blockade of LTB4-induced chemotaxis by bioactive molecules interfering with the BLT2-Galphai interaction”, J.Y. Kim, W-. K. Lee, Y. G. Yu, J. H. Kim, Biochem Pharmacol., 2010, 79(10), 1506p


“Functional reconstitution of the human serotonin receptor 5-HT(6) using synthetic transmembrane peptides”, W-. K. Lee, J. J. Han, B-. S. Jin, D. W. Boo, Y. G. Yu, Biochem Biophys Res Commun., 2009, 390(3), 815p


“Expression and purification of human mPGES-1 in E. coli and identification of inhibitory compounds from a drug-library”, W. I. Kim, K. A. Choi,H. S. Do, Y. G. Yu, BMB Rep., 2008, 41(11), 808p


“Characterization of the InsP6-dependent interaction between CK2 and Nopp140”, W-. K. Lee, S. Y. Lee, W. I Kim, Y. H. Rho, Y. S. Bae, C. Lee, I. Y. Kim, Y. G. Yu, Biochem Biophys Res Commun., 2008, 376(2), 439p



“Activation of NF-kappaB by alloferon through down-regulation of antioxidant proteins and IkappaBalpha”, M. J. Ryu, V. Anikin, S. H. Hong, H. Jeon, Y. G. Yu, M. H. Yu, S. Chernysh, C. Lee, Mol Cell Biochem., 2008, 313(1-2), 91p


“Interaction and assembly of HBV structural proteins: novel target sites of anti-HBV agents, I. G. Choi, Y. G. Yu, Infect Disord Drug Targets, 2007, 7(3), 251p


“An inhibitory compound against the interaction between Gαs and the third intracellular loop region of serotonin receptor subtype 6 (5-HT6) disrupts the signaling pathway of 5-HT6”, Y. H. Choi, H. Kang, W-. K. Lee, T. Kim, H. Rhim, Y. G. Yu, Exp. Mol. Med., 2007, 39, 335p


“Protein kinase CK2 is inhibited by human nucleolar phosphoprotein p140 in an inositol hexakisphosphate-dependent manner”, Y. K Kim, K. J. Lee, H. Jeon, Y. G. Yu, J. Biol. Chem., 2006, 281, 36752p


“Doxorubicin binds to un-phosphorylated form of hNopp140 and reduces protein kinase CK2-dependent phosphorylation of hNopp140”, Y. K. Kim, W-. K Lee, Y. Jin, K. J Lee, H. Jeon, Y. G. Yu, J. Biochem. Mol. Biol., 2006, 39, 774p